Toxicity of pertussis vaccine.
نویسندگان
چکیده
منابع مشابه
Whole cell pertussis vaccine: reducing toxicity.
Since introduction of the pertussis vaccine in 1940's the morbidity and mortality due to the infection has been markedly reduced all over the world. However the adverse effects of the inactivated whole cell pertussis vaccine like pain, swelling at the site of injection, fever, vomiting anorexia, persistent crying & drowsiness have been the cause of great concern, till date. Also the safety conc...
متن کاملPertussis Vaccine Testing for Freedom-from-toxicity.
The results of 9.5 years of official testing of vaccines containing pertussis vaccine, plain or adsorbed with alum, Al(OH)(3), or AlPO(4), are reported. Toxicity was evaluated by weight changes in mice at 3 and 7 days after injection and intercurrent deaths. Toxicity was encountered during the early use of AlPO(4) in pertussis vaccine products, with a special product and quadruple-antigen vacci...
متن کاملThe potency, toxicity and immunogenicity of glutaraldehyde inactivated pertussis vaccine
Whole cell pertussis vaccine was prepared by inactivation of Bordetella pertussis organisms with glutaraldehyde under optimal conditions (0.05% glutaraldehyde at room temperature for 10 minutes). This glutaraldehyde inactivated pertussis vaccine-1 (GIPV-1) was compared to the routinely produced heat inactivated (56°C for 30 minutes) pertussis vaccine (HIPV) for potency, toxicity and immunogenic...
متن کاملPertussis Vaccine Effectiveness in the Setting of Pertactin-Deficient Pertussis.
BACKGROUND In the United States, the proportion of Bordetella pertussis isolates lacking pertactin, a component of acellular pertussis vaccines, increased from 14% in 2010 to 85% in 2012. The impact on vaccine effectiveness (VE) is unknown. METHODS We conducted 2 matched case-control evaluations in Vermont to assess VE of the 5-dose diphtheria, tetanus, and acellular pertussis vaccine (DTaP) ...
متن کاملCollaborative study on test systems to assess toxicity of whole cell pertussis vaccine.
A collaborative study has been carried out to establish the precision and accuracy of five test systems for the assessment of the toxicity of whole cell pertussis vaccine. To this end, six vaccines, including both "normal" and "abnormal" products with respect to arbitrary levels of Pertussis toxin and/or potency were tested. The study included in vivo test systems as the Mouse Weight Gain (MWG)...
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ژورنال
عنوان ژورنال: BMJ
سال: 1982
ISSN: 0959-8138,1468-5833
DOI: 10.1136/bmj.284.6332.1817-a